CD4 and cancer: According to the obtained results, hematopoietic stem cell, stroma score, Cancer-associated fibroblast, and endothelial cell were significantly positively correlated, whereas T cell CD4 + memory, T cell CD4 + Th2, and T cell CD4 + memory activated were negatively correlated (Fig. 7A).The ESTIMATE algorithm examined the above-mentioned results and discovered that the immune score, stromal score, and ESTIMATE score were higher and that the tumor purity was lower in the high-risk subtype(Fig. 7B).