CD4 and neoplasm: CRISPLD2 makes a vital impact on maintaining cell structure, which can participate in immune response, inhibit inflammation, or be involved in cell motility40.G0S2 has been identified as a tumor suppressor that opposes MYC activity41,which related to neutrophils, activated and resting mast cells, M0 and M1 macrophages, regulatory T cells (Tregs), resting dendritic cells, together with resting CD4 memory T cells42.