Owing to the pyroptosis mediated by NLRP3/Caspase-1/GSDMD is also an essential pathway to the pathogenesis of inflammatory-related male infertility such as male genital tract diseases and abnormal spermatogenesis [72, 73], we speculate whether the improvement of PQQ promote T synthesis came into play in management of the LCs pyroptosis induced by obesity. The gene discussed is GSDMD; the disease is obesity due to melanocortin 4 receptor deficiency.