Abundant cross-sectional and prospective studies have attested a significantly negative correlation between the dyslipidemia (e.g., increased level of TC, TG, LDL) and decreased free T and SHBG levels in overweight men, as for the dyslipidemia has become an independent risk factor for suppressive T-converting proteins (StAR and P450scc) levels in LCs [46–48]. This evidence concerns the gene SHBG and metabolic syndrome.