WDR1 and glioblastoma: Interestingly, we also observed that WDR1-deficient PDCs showed an attenuated invasion ability, consistent with a previous study showing that high WDR1 expression in GBM is positively correlated with poor prognosis.35 Based on the obvious effect of WDR1 knockout on resistance to GA-amide treatment, we built WDR1 overexpressed cell line to investigate whether the overexpression of WDR1 could enhance the sensitivity of PDCs to GA-amide (Supplementary Fig. 9a).