To further investigate whether cGAS-STING pathway mediated the observed effect of Dusp1 in AKI mice, we generated mice with double knockout of Dusp1 and Sting by crossing Dusp1−/− mice with Ksp-Cre/Sting flox/flox mice and subjected them to IRI for 48 h (Fig. 9A). The gene discussed is CGAS; the disease is acute kidney injury.