Leaked mtDNA can act as an endogenous ligand for cGAS, thus inducing an innate immune response through the STING pathway [18, 19] We found that Dusp1 deletion further activates the cGAS-STING pathway, accompanied by aggravated renal injury, in an ischemic AKI mouse model (Fig. 6). The gene discussed is STING1; the disease is acute kidney injury.