By mining and integrating both our own and additional published genomic and transcriptional data from well-characterized cHL cell lines, we identified and verified the same c.295 T > C (chr6:394,899 T > C; hg38) variant in the IRF4 gene in 2 of 7 HL cell lines, namely the B-cell-derived HRS cell lines L428 and U-HO1 (Fig. 1a and Supplementary Fig. 1a). The gene discussed is IRF4; the disease is classic Hodgkin lymphoma.