CD8A and neoplasm: Next, we isolated tumour-infiltrating TNFR2+CCR8+ Tregs and TNFR2−CCR8− Tregs from tumour tissues and found that TNFR2+CCR8+ Tregs, rather than TNFR2−CCR8− Tregs, strongly suppressed the proliferation of CD8+ T cells (Figure 3E).