AIRE and autoimmune polyendocrine syndrome type 1: Approximately 57% of the known autoimmune targets in human APS1 (n = 30 proteins) (11) were orthologous to putative autoreactive targets in Aire–/– mice and approximately 43% of genes with known Aire-dependent thymic expression (42) were among Aire–/–-specific reactivities by PhIP-seq (Figure 4A).