These included proteins expressed by pancreatic islet cells (Ptch1, Disp1, Pck1, and Cacna1e) as well as proteins known to be associated with diabetes mellitus susceptibility or glucose metabolism (Adcy8, Perm1, Sorbs1, and Pla2g6; Supplemental Figure 4, B and C). This evidence concerns the gene PTCH1 and diabetes mellitus.