In rodent models, blockade of ACE2 decreases insulin-stimulated glucose uptake and microvascular blood flow in muscle and insulin receptor signaling (PI3K/Akt activation) in the liver and adipose tissue (296, 297), and exacerbates diet-induced glucose intolerance and insulin resistance by reducing the expression of GLUT4 in skeletal muscle (298). This evidence concerns the gene ACE2 and Insulin resistance.