Similar to fluctuations in nutrient status, SARS-CoV-2 infection promoted GP73 production and secretion in cultured hepatocytes and in mice, inducing hepatocyte glucose production and hyperglycemia in mice, whereas GP73 blockade inhibited SARS-CoV-2-induced increases in gluconeogenesis in vitro and lowered elevated fasting blood glucose levels in infected mice (246). The gene discussed is GOLM1; the disease is Hyperglycemia.