On activation, T-bet+ secrete the proinflammatory C-X-C motif chemokine 10/interferon-gamma-induced protein 10 (CXCL10), which exacerbates adipose tissue inflammation and glucose intolerance in obesity (119-121) and plays a key role in the pathogenesis of infections by human coronaviruses, having emerged as a prognostic marker for disease severity in COVID-19 (122). This evidence concerns the gene CXCL10 and infection.