To fill this important knowledge gap, we investigated the associations of baseline and serial changes in WBC count, platelet count, CRP, and D-dimer from whole blood samples that were consecutively measured on days 1, 3, and 7 since admission with a variety of clinical outcomes, including 30- and 60-day morality, ICU transfer, and overall survival (OS) among the 456 hospitalized patients with COVID-19 who were admitted to Massachusetts General Hospital (MGH) between March and June 2020 (surge 1) and January to March 2021 (surge 2). This evidence concerns the gene CRP and COVID-19.