PTGFR and pulmonary fibrosis: To assess the role of PGF2α signaling in pulmonary fibrosis, we first employed a genetic approach by crossing SftpcI73T mice to a Ptgfr-deficient line (Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.172977DS1) with resultant genotypes lung Ptgfr mRNA levels reflecting the loss of 1 or 2 alleles (Figure 1A) and without changes in overall urinary prostanoid levels (Supplemental Figure 1B).