For this study, the role of FPr signaling was first assessed in a clinically relevant model of spontaneous pulmonary fibrosis, the IER-SftpcI73T mouse, which we have shown to recapitulate many characteristic features of IPF, including histopathology, restrictive physiology, and biomarkers also found in human IPF. The gene discussed is FPR1; the disease is pulmonary fibrosis.