Out of these NRGs, 19 NRGs (EGLN3, HILPDA, HMBS, HYOU1, BNIP3, etc.)were found to be enriched in glioma tissues while 13 genes (SLC4A1, IL6, EPAS1, ACE, HMOX1, etc.)were decreased compared to normal tissues (Figure 1A). This evidence concerns the gene HMBS and glioma.