Out of these NRGs, 19 NRGs (EGLN3, HILPDA, HMBS, HYOU1, BNIP3, etc.)were found to be enriched in glioma tissues while 13 genes (SLC4A1, IL6, EPAS1, ACE, HMOX1, etc.)were decreased compared to normal tissues (Figure 1A). Here, HMBS is linked to central nervous system cancer.