The total U-LH-ir and U-FSH-ir levels were significantly higher in LPP than in EPP and similarly higher in EP than in LPP girls; however, the above-mentioned urinary gonadotropin immunoreactivity levels were not higher in LP than in EP girls (Fig. 2A, B). This evidence concerns the gene PLOD1 and autosomal erythropoietic protoporphyria.