In line with our findings, Gazzerro et al. and Panicucci et al. have reported that blockade of P2 X 7 receptor exerts an anti-fibrotic effect and improves muscular function via decreasing concentration of fibrotic mediators as TGF-β and CTGF in experimental models of muscular dystrophies [46, 47]. The gene discussed is CCN2; the disease is muscular dystrophy.