First, mPD‐L1 promotes tumor progression and inhibits apoptosis by preventing cytotoxic effects of IFN on tumor cells through the inhibition of the STAT3/caspase‐7 signaling pathway.[27] Additionally, mPD‐L1 can also inhibit tumor cell apoptosis by suppressing tumor autophagy and activating the mTOR pathway.[28] Second, studies have also demonstrated that the cytoplasmic domain of mPD‐L1 is critical in regulating the stability of mPD‐L1 and mediating the immune escape of tumor cells. This evidence concerns the gene STAT3 and neoplasm.