Various types of sPD‐L1 isoforms, which lack transmembrane domain, are identified in a melanoma model and in patients with NSCLC.[39, 41] Besides, another sPD‐L1 is also characterized for lacking transmembrane domain and dimerization of cytoplasmic C‐tail domain.[42] These findings have significantly improved our grasp of structural variation of extracellular PD‐L1. Here, SPDL1 is linked to melanoma.