CD274 and neoplasm: Since its detection in collected circulating tumor cells (CTCs) by immunofluorescence, a growing body of research have been performed, illustrating cPD‐L1 location and roles.[17, 30] Unlike mPD‐L1 which primarily localizes on the cell membrane, cPD‐L1 is found in the inner part of tumor cells, potentially being protected from binding by current PD‐L1 antibodies.