On the one hand, exoPD‐L1 acts on the immediately adjacent cancer cells and macrophage cells by paracrine signals, facilitating PD‐L1 expression in adjacent tumor cells and M2 polarization in adjacent macrophage cells, and finally inducing immune evasion.[49] On the other hand, they can enter into circulation, spread distantly to the lymph nodes, and exert suppressive effects on a newly generated T cell that can express PD‐1. The gene discussed is CD274; the disease is cancer.