In addition, recent studies indicated that the spatial heterogeneity expression of PD‐L1 in tumor cells seemed more responsible for the unsatisfactory efficacy of anti‐PD‐L1 antibodies.[10] In recent years, emerging studies have demonstrated that PD‐L1 is not only expressed on the tumor cell membranes but also broader cellular substructure of tumor cells, such as cytoplasm, nucleus and extracellular vesicles, etc.[11] Moreover, PD‐L1 can also be recycled between the cytoplasm and the membrane (Figure 1). The gene discussed is CD274; the disease is neoplasm.