In tumor cells, high expression of epidermal growth factor (EGF)/EGFR activates B3GNT3, leading to cPD‐L1 glycosylation.[97, 98] STT3 is an ER N‐glycosyl transferase that catalyzes the first N‐linked glycosylation.[99] On the one hand, STT3 is critical for epithelial–mesenchymal transition (EMT)‐mediated cPD‐L1 protein induction. The gene discussed is B3GNT3; the disease is neoplasm.