EP300 and breast carcinoma: HBXIP can induce acetylation modification of mPD‐L1 through p300, and aspirin can inhibit HBXIP to prevent mPD‐L1 acetylation by p300, leading to tumor growth suppression in breast cancer.[55] Additionally, palmitoyltransferase DHHC3 catalyzes the palmitoylation of mPD‐L1, which stabilizes mPD‐L1 by inhibiting ubiquitination.