Twelve studies, including 1888 patients, analyzed the association between aPS/PT antibodies and thrombosis, observing a statistically significant association between aPS/PT IgG/IgM positivity and thrombotic events (mean OR 6.8 [95% CI 3.18–16.4], p < 0.05), confirmed when analyzing aPS/PT IgG (mean OR 6.7 [95% CI 3.04–21.6], p < 0.05) and aPS/PT IgM (mean OR 4.35 [95% CI 1.54–17.77], p < 0.05) separately. The gene discussed is CD40LG; the disease is Venous thrombosis.