The observation that proteolytic cleavage of PL-binding site in the C-terminal loop in D5 abolished antibody binding to β2GPI suggested that the antigenic site resides in close vicinity.41 A subsequent study found an even higher positivity rate of anti-β2GPI in 33 children with atopic dermatitis (54.5%), with a polarization towards D4/5 reactivity (33%). Here, APOH is linked to atopic eczema.