In fact, β2GPI/HLA-DR complexes were found in uterine decidual tissues from patients with APS.51 Recently, by conducting prospective, multicentre, cross-sectional study, Tanimura et al.53 reported that women with unexplained recurrent pregnancy loss (RPL) had anti-β2GPI/HLA-DR antibodies. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.