SETD2 is reported to be the only histone H3K36 trimethyltransferase involved in different biological processes, including DNA repair, transcription initiation and elongation20, 21, 22 SETD2‐mediated epigenetic alterations are associated with many diseases, especially in RCC.23, 24, 25. The gene discussed is SETD2; the disease is renal cell carcinoma.