Our recent studies reported that SETD2 plays important roles in intestinal immunity,27 suppressing inflammatory bowel disease,28 V(D)J recombination in normal lymphocyte development,29 attenuating experimental colitis,30 inhibiting pancreatic carcinogenesis,31 bone marrow mesenchymal stem cell differentiation,32 genomic imprinting, embryonic development,33 spermiogenesis34 and cutaneous wound healing.35 Here, SETD2 is linked to colitis.