SETD2 and renal fibrosis: To further investigate whether SETD2 contributes to renal fibrosis, we generated KspCre; VHLfl/fl mice (hereafter referred to as VHL−KO mice) and KspCre; VHLfl/fl; Setd2fl/fl mice (hereafter referred to as VHL−KO; Setd2−KO mice) (Figure 3A).