MAFA, NKX6.1, and PDX1 are the key beta cell transcription factors regulating beta cell function, identity and proliferation (Gao et al, 2014; Aigha & Abdelalim, 2020; Nishimura et al, 2022) while repression of these transcription factors mediates the loss of beta cell identity and progression of islet failure in T2D (Guo et al, 2013). Here, PDX1 is linked to type 2 diabetes mellitus.