Based on growing evidence, an important part of the underlying psychopathology of bipolar disorder may be seen in persistent malfunction in the expression and role of mineralocorticoid and glucocorticoid receptors in the hippocampus, which mediates the effects of glucocorticoids in the form of negative feedback binding and is in a clear connection with the impact of stressful life events on the HPA axis (Juruena et al., 2021). This evidence concerns the gene NR3C1 and bipolar disorder.