Cardiovascular diseases (CVDs) are one of the largest cause of human death.[140] Among all CVDs, acute myocardial infarction (AMI) is a disease worth noting, that is, the sudden interruption of blood flow to the heart.[141] Cardiac troponin I (cTnI) is recognized as one of the highly recommended biomarkers because of its extremely high sensitivity and specificity in the diagnosis of myocardial injury.[142] Prajesh et al. Here, TNNI3 is linked to acute myocardial infarction.