HIF1A and neoplasm: Upon the stimulus of the tumor acidic microenvironment, the PMP NPs would disintegrate to release Mn2+ for MRI and the photosensitizer Ce6 would be released to produce ROS under irradiation while ACF blocks the HIF‐1α /VEGF pathway during the burst release of VEGF in tumor triggered by PDT, leading to improved curative effect.[54]