In addition to the strategy of improving tumor hypoxia, the PDT efficacy could also be enhanced through blocking the hypoxia‐inducible factor‐1α/vascular endothelial growth factor (HIF‐1α/VEGF) pathway.[54] Based on this strategy, Zhang and co‐workers applied photosensitizer and acriflavine(ACF)‐loaded porous manganese phosphate (PMP) NPs as the photoactivable synergistic system which imparts ROS triggered cytotoxicity in coordination with HIF‐1α /VEGF inhibitor which prevents tumor growth and development as well as treatment escape signaling pathway. This evidence concerns the gene HIF1A and neoplasm.