Women who have had their ovaries removed exhibit cognitive decline and high levels of pro‐inflammatory cytokines, such as IL‐1 and TNF‐α.[21] Mechanistically, estrogen could suppress inflammation by inhibiting NF‐κB activity, NLRP3 inflammasome, and so forth.[22] In this study, we found decreased estradiol in the hippocampus of Cntnap4 knockdown mice, suggesting Cntnap4 insufficient may decrease the levels of estrogen. This evidence concerns the gene NFKB1 and Mental deterioration.