Women who have had their ovaries removed exhibit cognitive decline and high levels of pro‐inflammatory cytokines, such as IL‐1 and TNF‐α.[21] Mechanistically, estrogen could suppress inflammation by inhibiting NF‐κB activity, NLRP3 inflammasome, and so forth.[22] In this study, we found decreased estradiol in the hippocampus of Cntnap4 knockdown mice, suggesting Cntnap4 insufficient may decrease the levels of estrogen. Here, IL1B is linked to Mental deterioration.