A systematic literature search was conducted up until May 30, 2023, on the PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) databases with the following subject keywords and their Medical Subject Heading (MeSH) terms: (sacubitril valsartan) OR (neprilysin inhibitor) AND (angiotensin receptor inhibitor) AND (angiotensin converting enzyme inhibitor) AND (post myocardial infarction). The gene discussed is ACE; the disease is myocardial infarction.