GPX4 and neoplasm: In summary, metal‐based nanomaterials contain oxidizing metals Fe3+ and Mo6+ or other metal elements with the function of inhibiting GPX4 enzymes, performing function as indirect GSH depletion by directly depleting GSH or inhibiting GPX4 enzymes after entering tumor cells, disrupting tumor cell redox homeostasis, and causing a significant increase in cellular lipid peroxidation levels, and finally induce ferroptosis in tumor cells.