Meanwhile, metal‐based nanomaterials containing Mn2+, Zn2+, and other metal‐based materials with the ability to amplify the activation of the cCAS‐STING pathway exhibit a good ability to stimulate DCs maturation, which enhances the antigen‐presentation ability of DCs by directly targeting immune cells, while boosting the infiltration of CD8+ T cells at tumor sites for enhancing the anti‐tumor immune effect. This evidence concerns the gene CD8A and neoplasm.