prepared TaOx hollow nanospheres by the one‐step method at room temperature and added catalase during the synthesis process, so that the catalase was loaded inside the nanospheres, and then modified via layer by layer method to obtain stable TaOx@Cat nanospheres.[20] TaOx shell maintained the activity of catalase and catalyze the production of O2 from highly expressed H2O2 only at the tumor site, improving the hypoxic tumor environment, while sufficient O2 was able to further potentiate the radiotherapy sensitizing effect of the TaOx shell. This evidence concerns the gene CAT and neoplasm.