CALR and neoplasm: synthesized ZnPI and modified it by PEG to obtain ZnPI‐PEG nanoparticles with good stability.[97] ZnPI‐PEG NPs were able to weaken the coordination between Zn2+ and PI under acidic conditions due to the protonation process of nitrogen, in which Zn2+ could be released to induce strong CRT exposure on the surface of tumor cells, which had an ability to induce the similar levels to those of the classical ICD inducer OXA, effectively potentiating the subsequent metalloimmunology.