MnOx nanospikes with large mesoporous structures and good antigen loading capacity were synthesized by a rapid hydration process (Figure 3B).[45] It could be found that the MnOx NSs were biodegradable in the acidic environment of 4T1 tumor cells, where the high‐valent state of Mn would consume GSH, while the expression of GPX4 in tumor cells was significantly decreased. This evidence concerns the gene GPX4 and neoplasm.