Therefore, we hope to find a tumor treatment that causes tumor cell death in an orderly and peaceful manner.[81] Programmed cell death (PCD) was first proposed in 1951 and gradually became well accepted since then.[82] PCD mainly includes apoptosis, cell necrosis, autophagy, and ferroptosis, among which ferroptosis has attracted extensive attention due to its ability to evade multiple drug resistance (MDR).[83] Ferroptosis is a novel iron‐dependent, PCD, which mainly includes the following three mechanisms: (1) GSH‐based glutathione peroxidase 4 (GPX4) inactivation. This evidence concerns the gene GPX4 and neoplasm.