When tumor cells undergo ICD, they generate a series of signaling molecules, known as DAMPs, mainly include calreticulin (CRT) exposed to the cell surface, HMGB1 secreted by tumor cells, ATP molecules released by cells, and heat shock proteins (HSP70 and HSP90).[96] DAMPs released during ICD can bind to pattern‐recognition receptors (PRRs) on the surface of DCs, initiating a series of cytological responses that ultimately activate innate and adaptive immune responses. Here, HMGB1 is linked to neoplasm.