BCL2 and neoplasm: for tissue heating and ROS production under NIR laser irradiation, leading to cell necrosis.[79] CuS‐NiS2 triggered the apoptosis of human gastric cancer cells through the classic Bcl‐2/Bax routes and the novel MLKL/CAPG‐mediated necroptosis mechanisms.[80] Further research revealed that PTT/PDT with CuS nanocrystal‐modified Gd‐doped NPs would trigger tumor cell death by attacking the mitochondrial transmembrane potential and causing a change in the levels of anti‐apoptotic (Bcl‐2) and pro‐apoptotic (Bax) proteins, leading to ROS production.