HIF1A and neoplasm: Tumor hypoxia reverses DNA damage in the tumor redox environment and causes oxidative stress in radiotherapy and can lead to the overexpression of HIF‐1α, triggering metabolic reactions that weaken the radiation effect.[61, 62, 63] However, MnO2 can create extra H2O2 at the tumor site to compensate for the O2 shortfall in the hypoxic tumor microenvironment, markedly enhancing the therapeutic benefit of radiotherapy.