VEGFA and neoplasm: In addition, cytokines such as IL‐10, TGF‐β, G protein signaling 5 (RGS5) or anti‐vascular endothelial growth factor (VEGF) hinder immune cells from infiltrating into tumor tissues.[74] Combination use of small molecule inhibitors or engineering adoptive cells with functional peptides to inhibit the cytokine‐based pathway are another approach to improve cell infiltration.