GAD2 and epilepsy: A study divided the clinicopathological manifestations of GAD65-epilepsy into 3 stages according to the epilepsy etiology and disease course:[1] (1) reversible ongoing immune activation in the brain with no visible change in MRI; (2) subtle irreversible brain tissue damage manifested in MRI, associated with refractory epilepsy; (3) progressive damage including hippocampal sclerosis and more diffuse brain damage, which form the underlying structural causes of seizures and cognitive symptoms.