In an immunopathology study, the cytotoxic T-cells, GAD65-specific T-cells, and GAD65-specific T cell receptors were observed in GAD65-epilepsy patients, although GAD65 encephalitis generally had milder inflammation and relatively lower CD8/CD3 ratios in the brain tissues compared with the classic intracellular antigen-onconeural cases.[17]. This evidence concerns the gene CD8A and epilepsy.