An epidemiological study found that GAD65 Abs were detected in about 12.5% of unexplained newly-onset epilepsy, and 17% of LE in adults.[7] Patients with GAD65-epilepsy usually have systemic autoimmune disorders, which are mainly type 1 diabetes mellitus and thyroiditis.[8] Also, there might exist concurrent γ-aminobutyric acid (B) receptor-Ab in serum, as well as anti-TPO, antinuclear, antigliadin, and antiphospholipid Abs. This evidence concerns the gene GAD2 and diabetes mellitus.