The Matthews correlation coefficient algorithm was used to identify the top 10 Hub genes of GGQL in the treatment of COVID-19 comorbid with DM (see Fig. 3B), which are AKT1, IL6, TNF, VEGFA, IL1B, TP53, CCL2, EGFR, CXCL8 and JUN. The gene discussed is TP53; the disease is COVID-19.