As several reports found that the quercetin and kaempferol play a role in the treatment of coronavirus infection by regulating the body’s immunity, fighting inflammation, and antiviral activities by acting on multiple targets (such as NOS3, GSK3B, etc.)[34] and also plays an important role to prevent and/or ameliorate T2DM-related complications.[35] These results suggest that these active components and their corresponding targets are largely responsible for the therapeutic effect of GGQL against COVID-19 comorbid with DM. Here, NOS3 is linked to COVID-19.