In conclusion, NENs-related liver lesions, without characteristic symptoms, are rarely reported especially when accompanied by the primary disease and easy to misdiagnose, when the patient does not have a history of hepatitis or cirrhosis, the negative AFP and elevated NSE should be combined with imaging and immunohistochemistry before making a judgment, empirical diagnosis should be abandoned to avoid a wrong judgment. The gene discussed is ENO2; the disease is Hepatitis.