Meanwhile, the liver function tests demonstrated the more obvious elevation of GGT and AKP compared to AST or ALT, accompanied by obstructive jaundice alterations, also suggesting the potential metastatic liver lesion; the normality of AFP and CEA in the tumor markers could also exclude the liver A normal AFP and CEA in tumor markers excludes primary cancer, while an abnormal elevation of NSE may guide a consideration of the origin of the mass. This evidence concerns the gene AFP and cancer.