Moreover, Vordenbäumen et al showed that approximately 10% of patients with FD presented with “genuine” joint pain, episodes of unexplained fever and/or elevated markers of inflammation, that is, ESR and CRP, which were usually regarded by physicians as indicators of rheumatic disease.[12] Additionally a significant delay of FD diagnosis from first symptoms was often reported.[13,14] Joint discomfort is also a common clinical feature of FD.[15] Our patient also consulted the rheumatology department because of joint and muscle pain, high ESR and CRP. This evidence concerns the gene CRP and Fabry disease.