GLA and Fabry disease: FD is a rare disease with a predicted prevalence of 1/117,000 to 1/40,000 in the general population.[2,3] It was first reported by Fabry et al in 1898 and is an X-linked recessive disorder in which a mutation in the GLA gene caused deficiency of α-Gal A activity and consequent accumulation of glycosphingolipids mainly GL-3 and lyso-GL-3 in body fluids and lysosomes of the cells.