Through network pharmacological analysis, we found that the core targets of NST capsule in the treatment of IS include ALB, TNF, TP53, CASP3, VEGFA, SRC, MYC, PPARG, ICAM1, EGF, CCND1, etc. These targets have the effects of anti-oxidation, anti-apoptosis, anti-inflammation, regulation of blood lipids and atherosclerosis. The gene discussed is CASP3; the disease is atherosclerosis.