AKT1 and periodontitis: Previous studies have shown that the PI3K-Akt signaling pathway inhibits the apoptosis of periodontal ligament fibroblasts induced by high glucose,[29] while the MAPK signaling pathway is an important signal pathway for regulating the body inflammatory response and is highly relevant to periodontitis.[30] Among the 4 MAPK pathways, p38 is closely related to inflammation.