STAT3 and alkaline phosphatase measurement: Conversely, administration of recombinant PAP/HIP to PAP/HIP (-/-) mice reduced pancreatic inflammation and apoptosis, activated STAT3 and enhanced suppression of cytokine signaling 3 levels.[54] Another research has shown that the cerulein-induced reduction in cell viability and increase in apoptosis are reversed by overexpression of PAP-1 in PAP-1-transfected cells.[55] Reg3 levels of IL-22-deficient mice were significantly reduced in caerulein-induced AP, and IL-22 might regulate Reg3 expression in acinar cells via STAT3.[39]