Moreover, IL-22 can ameliorate lung injury caused by arginine induced SAP through STAT3 pathway,[41] and IL-22 protects intestinal mucosal barrier in SAP through decreasing colonic mucosal permeability, activating pSTAT3/Reg3 pathway, and restoring fecal microbiota abundance.[42] It has also been reported[43] that IL-22 enhanced the expression of antimicrobial peptides and antiapoptotic genes by activating STAT3 signaling pathway, and attenuated L-arginine-induced AP and intestinal mucosa injury in mice. The gene discussed is REG3A; the disease is alkaline phosphatase measurement.