IL22 and inflammatory bowel disease: A study shows the critical role of IL-22 in regulating intestinal cell homeostasis and promoting epithelial regeneration in inflammatory bowel disease.[17] It is noteworthy that IL-22 promotes epithelial regeneration, innate defense, and membrane mucus production, with similar effects in healthy individuals and inflammatory bowel disease patients.[18] Study[19] in mice with necrotizing enteritis have shown that IL-22 can ameliorate intestinal inflammation by promoting epithelial regeneration.