Since the vaccine was approved, studies have investigated the possibility of autoimmune disease following application of the vaccine.[5–9] Here, we report the clinical features of a case of Isaacs syndrome that occurred after the second dose of qHPV vaccination and their response to symptomatic and immunomodulatory treatment, which was positive for CASPR2 antibodies and positive for LGI1 antibodies with positive antiphospholipid antibodies and positive anti-sulfatide antibodies, TPO and ATG, IgG E. Here, CNTNAP2 is linked to autoimmune disease.