TFAP2A and branchiooculofacial syndrome: Branchiooculofacial syndrome (BOFS) is a rare autosomal dominant disorder with a diverse clinical phenotype that can present with branchial skin defects, ocular abnormalities, characteristic facial anomalies, as well as ectopic thymus, subscale cysts, renal and dental abnormalities.[1] Milunsky found in 2008 that TFAP2A gene mutations are linked to BOFS, and that multiple symptoms can result from the same locus.[1] Few cases of neonatal BOFS have been reported.