It is found on the surface of many ovarian cancer cells.[17] MUC16 expression correlates with disease progression and metastasis, such as pancreatic cancer, colorectal cancer, and gastric adenocarcinoma.[18,19] Recent studies have revealed that MUC16 is one of the most frequently mutated genes in hepatocellular carcinoma,[20] gastric cancers,[21] and melanoma.[22] However, no studies have described the MUC16 mutations and their association with TMB and tumor-infiltrating immune cells in LUAD patients. The gene discussed is MUC16; the disease is melanoma.