INS and metabolic disease: p62,a 62kDa protein, was originally identified as a phosphotyrosine-independent ligand of the Srchomology 2 (SH2) domain of the lymphatic-specific Src family tyrosine kinase p56lck.[45] Studies have shown that p62 is involved in human metabolic processes, such as lipogenesis,[46] insulin signaling[47] and inflammation.[48] p62 plays a key role in the incidence of many metabolic diseases, including gout[49] and thyroid diseases.[50] p62 may be a potential mechanism for the causal association between gout and thyroid disease.