DNMT1 and thyroid gland disorder: GD patients have low methylation and lower DNMT1 expression in B and T lymphocytes.[43] In addition, DNA methylation, such as MAPK, Ras, and WNT, may be involved in associated hypothyroidism.[44]These studies suggest that epigenomics may be a key bridge in the study of the co-pathogenesis of gout and thyroid disease, the underlying mechanisms of which need to be further studied.