FOXO1 and major depressive disorder: Among these, safflower can improve stress-induced depression syndrome in surgical or stressed rats by regulating luteinizing hormone, follicle-stimulating hormone, and monoamine levels.[37] Baicalin extracted from Scutellaria baicalensis relieves CUMS-induced depression-like symptoms and improves neuroinflammation-induced depression-like behaviors by inhibiting toll-like receptor 4 expression through the phosphatidylinositol 3-kinase, protein kinase B (AKT), and FoxO1 pathways.[38] Naringenin and apigenin are the 2 components of Chrysanthemum morifolium.