MADCAM1 and inflammatory bowel disease: The precise intricacies governing this transmigration are yet to be fully decoded, but heightened expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in colonic lamina propria vessels, observed in IBD patients and specific animal models [27–29], insinuates the pivotal role of an augmented α4β7 integrin and MAdCAM-1 interplay in fast-tracking the oral Th17 cell influx into the inflamed gut (Fig. 2).