The authors highlighted specific CpG sites in four genes, VMP1/MIR21, CORO1B, SDK1, and SUMF2. Notably, CpG cg16936953 in VMP1/MIR21 was also the most significant locus in an independent study by Smith et al. comparing patients treated with chemotherapy and those untreated (n = 61 breast cancer patients) [4]. Here, MIR21 is linked to breast cancer.