Given that PRKAG2 encodes the regulatory subunit of AMP-activated protein kinase (AMPK) [31], it is intriguing to investigate whether PRKAG2-AS is involved in regulating AMPK signaling via the transcriptional regulation of PRKAG2. Energy sensing and regulation are activated in cardiovascular diseases, such as myocardial ischemia and stress overload-induced myocardial hypertrophy. This evidence concerns the gene PRKAG2 and cardiac hypertrophy.