NRG3 and astrocytoma (excluding glioblastoma): In TCGA IDHmut astrocytomas, 9 of these genes, including NRG3, had significantly (p < 0.05, one-sided Wilcoxon rank-sum test, log2FC < − 1) lower expression in cases with hemizygous loss of gene, compared to neutral copy number (Additional file 1: Table S13).