In the GLASS data from matched IDHmut astrocytoma tumors of patients with tumor progression to grade 4 (n = 33, Additional File 1: Table S11), NRG3 was hemizygously deleted in 14 cases upon progression to grade 4, 13 of which were concomitant with a PTEN loss (Additional file 1: Table S12, Additional file 2: Fig. S2f). Here, NRG3 is linked to neoplasm.