In our TCGA data analysis, NRG3 showed reduced expression in grade 4 tumors, and low expression was associated with worse OS in IDHmut astrocytomas both in univariate and multivariate analysis, consistent with previous reports on its prognostic role in diffuse glioma in general [57–59]. The gene discussed is NRG3; the disease is astrocytoma (excluding glioblastoma).