NRG3 and astrocytoma (excluding glioblastoma): Furthermore, low NRG3 expression (below 7.7 i.e. mean expression in the whole TCGA diffuse glioma cohort) was associated with worse survival in the entire diffuse glioma cohort and within IDHmut astrocytomas (p < 0.0001, log-rank test) (Fig. 2i and Additional file 2: Fig. S2c).