CD80 and neoplasm: Therefore, the M1/M2 phenotype of PMs was differentiated by CD80 (for M1) and CD206 (for M2), which indicated that the initial polarization (at two weeks) of PMs was dominated by an anti-tumor M1 phenotype (Fig. 2B-C) and as the tumor progressed, PMs gradually polarized toward an M2 phenotype, with only a small M1 macrophages proportion at the late stages (nine weeks) (Fig. 2B-C).