EGF and neoplasm: PMs can be switched to tumor-associated macrophages (TAMs) in ascites with pro-tumor effect by releasing various soluble mediators, including IL-6, IL-10, CCL18, CCL22, TNF-α, TGF-β, and EGF that triggers pro-tumorigenic signaling pathways in tumor cells and infiltrating leukocytes in the TME [6–8].