Transcriptome analysis in sheep revealed the higher activity of the gene CDC42BPG, which regulates the activity of small GTPases (which act as molecular switches or timers in many basic cellular processes such as signal transduction, protein biosynthesis, translocation of proteins across membranes, etc.). Also on OAR21, the gene encoding Hmg-CoA reductase 1 or SYVN1 degradation may mediate resistance to diabetic retinopathy, as shown in the study on mice [161]. Here, SYVN1 is linked to diabetic retinopathy.