AFP and hepatocellular carcinoma: The analyses demonstrated that a high level of AFP serum protein (≥ 3.8 ng/mL) helps to distinguish HCC from primary liver diseases with the AUC value of 0.817 (95%CI: 0.785–0.849), 68.6% sensitivity (95%CI: 62.9–73.8), and 78.2% specificity (95%CI: 73.7–82.2).