The results from FDM guinea pigs, FDM mice and highly myopic adults indicated that the lncRNA-XR_002792574.1/miR-760-3p/Adcy1 axis might have a potential relationship with the cGMP/PKG and apelin pathways and that lncRNA-XR_002792574.1 might inhibit the cGMP/PKG and apelin signaling pathways in RGCs through miR-760-3p/Adcy1, thereby causing RGC damage in myopia. Here, ADCY1 is linked to myopia.