Gene knockdown of ccdc80 in zebrafish caused decreased expression of Col1a1 while immunohistochemistry studies in a rat model of pulmonary hypertension demonstrated Ccdc80 protein to be induced, thus implying different roles of this protein in the pathogenesis of pulmonary hypertension and vascular remodeling [112]. The gene discussed is COL1A1; the disease is pulmonary hypertension.