We hypothesize that this discrepancy is due to the fact that our ICU receives patients with a great myriad of affections, being the most frequent causes of admission: sepsis, oncological diseases and cardiovascular diseases, which are pathologies that are frequently associated with cardiovascular dysfunction and consequently elevation of biochemical markers (troponins, D-dimer, NT-pro BNP). The gene discussed is NPPB; the disease is cardiovascular disorder.