To further investigate the functional interaction of circHERC1 and HMGB1 in lung cancer cells, EdU experiments, CCK8 experiments and apoptosis detection experiments were performed, which showed that sh-HMGB1 did not eliminate the promoting effects of circHERC1 overexpression on cell proliferation (Fig. 5c and Fig. S6e), and the inhibition of apoptosis (Fig. S6f). This evidence concerns the gene HMGB1 and lung carcinoma.