At the same time, the expression of FOXO1, HMGB1, pERK1/2, pIKBα and pATK in the tumor tissues of mice was verified by western blot analysis and immunohistochemistry, and the results were consistent with the above in vitro experimental results (Fig. 8d, Fig. S15, and Fig. S16). Here, HMGB1 is linked to neoplasm.