HMGB1 and lung cancer: To further investigate the functional interaction of circHERC1 and HMGB1 in lung cancer cells, EdU experiments, CCK8 experiments and apoptosis detection experiments were performed, which showed that sh-HMGB1 did not eliminate the promoting effects of circHERC1 overexpression on cell proliferation (Fig. 5c and Fig. S6e), and the inhibition of apoptosis (Fig. S6f).