Therefore, other immune checkpoint such as lymphocyte activating 3 (LAG3), T-cell immunoglobulin mucin-3 (TIM3), and T cell immunoreceptor with Ig and ITIM domains (TIGIT) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) were also studied as therapeutic target in NPC. Here, LAG3 is linked to nasopharyngeal carcinoma.