Other than that, LMP1-activated PI3K/Akt/mTOR through carboxy-terminal activating region (CTAR)1 has promoted resistance in NPC and defected the DNA repair system by modulating the expression of human miR-21 and inhibiting the activity of forkhead box O3a (FOXO3a), respectively [221, 222]. This evidence concerns the gene FOXO3 and nasopharyngeal carcinoma.