TACSTD2 and familial pancreatic carcinoma: should be discussed and summarized in a Table HuNbTROP2-HSA-MMAE exhibited desirable binding activity, endocytosis efficiency, inhibition of cell viability, and induction of apoptosis in TROP2-positive pancreatic cancer cells and also showed potent antitumor ability in vivo, which raises new possibilities for the treatment of pancreatic cancer and other TROP2-positive tumors.